The helpline will offer psychological support and signpost to other services.
Over 1,500 volunteers from charities such as Hospice UK and the Samaritans, will offer psychological support and signpost to other services including financial assistance and specialist bereavement support.
The phone line 0300 131 7000 will be open between 7am and 11pm daily with a text message service also offered 24/7 on 85258.
Prerana Issar, Chief People officer for the NHS, said: “We need to do everything we can to support our incredible NHS people as they care for people through this global health emergency.
“That’s why we have developed a range of support for all NHS staff, from one-to-one mental health support to a sympathetic voice to confide in.
“The NHS is rightly doing everything we can for our staff, but the best thing the public can do for nurses, doctors and other NHS staff, is to protect them by staying indoors and washing your hands.”
Dame Donna Kinnair, RCN Chief Executive and General Secretary, said: “The skill, professionalism and bravery of nursing staff have been on full display as they rise to the challenge of this global pandemic. But the added pressure is taking a toll on an overstretched workforce. So we are pleased to see increased mental health support for nursing staff and additional help for those with financial problems or bereavement.
“Acknowledging that nurses need dedicated resources for their mental health is just the start, and we hope that staff in all parts of the UK will be able to benefit from this sort of support during this pandemic, and in the future.”