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Cytochrome P450 Inducers & Inhibitors Mnemonic

An easy way to remember the mnemonic is; CRAP GPs spend all day on SICKFACES.com.


11 September 2020
Medications

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Cytochrome P450 enzymes are essential to metabolise many medications.

Cytochrome P450 (CYP450) enzymes can be inhibited or induced by some drugs, resulting in significant drug interactions that can cause unanticipated adverse reactions or therapeutic failures.



An easy way to remember the mnemonic is; CRAP GPs spend all day on SICKFACES.com.

Cytochrome P450 Inducers

CYP450 inducers reduce the concentration of drugs metabolised by the CYP450 system.

The mnemonic CRAP GPs can be used to easily remember common CYP450 inducers.

  • Carbemazepines
  • Rifampicin
  • Alcohol
  • Phenytoin
  • Griseofulvin
  • Phenobarbitone
  • Sulphonylureas

Cytochrome P450 Inhibitors

CYP450 inhibitors increase the concentration of drugs metabolised by the CYP450 system.


The mnemonic SICKFACES.COM can be used to easily remember common CYP450 inhibitors.

  • Sodium valproate
  • Isoniazid
  • Cimetidine
  • Ketoconazole
  • Fluconazole
  • Alcohol & Grapefruit juice
  • Chloramphenicol
  • Erythromycin
  • Sulfonamides
  • Ciprofloxacin
  • Omeprazole
  • Metronidazole

Common Interactions

Exampled of drugs that commonly interact with CYP450 enzyme inhibitors and inducers are; Warfarin the Combined Contraceptive Pill, Theophylline, Corticosteroids, Tricyclics, Pethidine, and Statins.




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